Therapeutic Activity of High-Dose Intratumoral IFN-b Requires Direct Effect on the Tumor Vasculature
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Therapeutic activity of high-dose intratumoral IFN-β requires direct effect on the tumor vasculature.
Endogenous type I IFN production after innate immune recognition of tumor cells is critical for generating natural adaptive immune responses against tumors in vivo. We recently have reported that targeting low doses of IFN-β to the tumor microenvironment using tumor-specific mAbs can facilitate antitumor immunity, which could be augmented further with PD-L1/PD-1 blockade. However, sustained hig...
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تاریخ انتشار 2014